IndraLab

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NS 1619 activates KCNMA1. 31 / 31
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"Physiological experiments further support the origin of mitoBK (Ca) as a Kcnma1 product because NS1619 mediated cardioprotection was absent in Kcnma1 knockout mice."
23754429
ctd
No evidence text available
21413024
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"Both native and recombinant BK channel activities are enhanced by the BK channel activator NS1619 and inhibited by the selective blocker paxilline [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23344746
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"Furthermore, we found that intrathecal administration of the specific BK channel activator NS1619 had no significant effect on nociceptive thresholds in control rats but dose dependently attenuated mechanical allodynia and hyperalgesia in nerve-ligated rats."
19457113
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"NS1619, niflumic acid, and phloretin were tested by using excised inside-out membrane patches from HEK 293 cells and were found to increase the activity of hSlo BK channels and produce a leftward shift in the G/Gmax-versus-voltage relationship of these channels."
8700114
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"In pressurized, myogenic (60 mmHg) control arteries transfected with scrambled siRNA, the BK channel activator NS1619 stimulated a mean vasodilation of ~ 34.7 mum, and the specific BK channel inhibitor, iberiotoxin, produced a mean constriction of ~ 25.5 mum (XREF_FIG)."
28487419
eidos
"Furthermore , in cell lines HK-2 , NRK49 , and NRK-52E , BK channel activation by NS1619 led to increased caveolae formation and facilitated localization of TGF-beta receptors in the microdomains of lipid rafts ."
34968553
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"Thus, the primary effect of the BK channel activator NS1619 was to increase the P o or channel gating."
23344746
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"In the presence of BAPTA-AM, the BK channel modulators NS1619 and 12,14-dichlorodehydroabietic acid increased the BK current at concentrations of 10muM or more showing clear concentration dependency, whereas in its absence, the effect of both compounds was detected only at 30muM."
23138150
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"Indeed Stowe et al. found that pre-treatment with the BK channel activation by NS1619 in isolated perfused guinea pig hearts attenuated mitochondrial calcium accumulation following an ischemic event."
25346695
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"Similarly, addition of the selective BK channel activator NS-1619 inhibited the spontaneous Ca 2+ oscillations in a readily reversible manner."
12726817
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"The BK channel activator NS1619 (10 muM) enhanced the P o by ~ 10-fold at +30 mV; subsequent application of the selective BK channel inhibitor paxilline (500 nM) blocked the activity."
23344746
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"The ability of leptin to modulate this activity requires activation of BK, but not K (ATP), channels as the effects of leptin were mimicked by the BK channel activator NS-1619, and inhibited by the BK channel inhibitors, iberiotoxin and charybdotoxin."
12482897
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"Unfortunately this can not be tested experimentally using Slo1 -/- mice, because post-IR Slo1 -/- hearts treated with NS1619 are incompetent at the contractile level (XREF_FIG and XREF_FIG), so they can not respond to nicotine anyway, regardless of their neuronal status."
23638385
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"Neither the BK channel blocker iberiotoxin (100nM) nor the BK channel activator NS-1619 (30muM) affected the H 2 O 2 -induced augmentation of spontaneous contractions (XREF_FIG, XREF_TABLE)."
29511675
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"From a pharmaco-genomic perspective, this is the first study to show that cardioprotection in the intact heart by the putative SLO1 activators NS1619 and NS11021 actually requires the Slo1 gene product (XREF_FIG and XREF_FIG)."
23638385
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"Another salient finding of our study is that intrathecal injection of the specific BK channel activator NS1619 dose dependently reduced mechanical allodynia and hyperalgesia in nerve-ligated rats."
19457113
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"The BK channel activation by NS 1619 appears to be independ- ent of ligand receptors, G-proteins or channel phos- phorylation."
8137869
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"Application of the selective BK channel activator NS-1619 (1 muM; Oelsen et al., 1994) also mimicked the actions of insulin, causing 50 +/-6.4% inhibition of the oscillatory activity (n = 31 cells / n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12726817
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"As a complementary approach we then examined the efficacy of a specific BK channel activator NS1619 in restoring the precision of pacemaking."
20505091
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"The human DSM single BK channel currents exhibited properties consistent with those reported for these channels in other systems : the mean single-channel conductance of more than 200 pS, P o highly dependent on the voltage and intracellular Ca 2+ concentration, enhancement of single-channel activity by the BK channel activator NS1619 and blockade by the selective BK channel inhibitor paxilline."
23344746
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"Iberiotoxin (50 nM), a selective blocker of large-conductance, voltage gated Ca2 +-activated K+ (K (Ca)) (BK) channel, dramatically increased both contraction amplitude and frequency whereas NS-1619 (30 microM), which increases BK channel activity, decreased them."
11736694
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"To explore the role of BK channels in regulation of apoptosis in human ovarian cancer cells, the effects of the specific BK channel activator NS1619 on induction of apoptosis in A2780 cells were observed."
18706395
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"Surprisingly, BK channel activator NS1619 (30muM) also increases the basal tension and amplitude in intact bladder strips."
29511675
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"It has also been reported that NS1619 activates Slo1 by functionally interacting with the S6/RCK linker connecting the transmembrane S6 segment with the cytosolic RCK1 domain [XREF_BIBR]."
28280418
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"They further demonstrated that mitochondrial uptake of K + was blunted by charybdotoxin and iberiotoxin and accelerated by the BK channel activator NS1619."
25346695
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"BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery."
11181423
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"NS19504 is a novel BK channel activator having a higher specificity than the commonly used BK channel activator NS1619, NS19504, which does not activate the small-conductance potassium channel (IK channels) while activating the BK channels (Nausch et al., 2014; Catacuzzeno et al., 2015)."
34276309
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"The relaxation to BK channel activator NS1619 was attenuated in the coronary artery with adenovirus transfected MuRF1."
32547406
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"In addition, pretreatment with BK channel activator NS-1619 or blocker iberiotoxin and PKC inhibitor Bis1 did not affect H 2 O 2 -elicited increases of the basal tension and amplitude."
29511675
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"The ATP activated K+ current was inhibited by iberiotoxin (200 nM), and it was potentiated by the BK channel activator NS-1619 (30 microM)."
8944628