IndraLab

Statements

SKP2 inhibits USP18. 6 / 6
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eidos
"In humans , binding of free ISG15 prevents proteasomal degradation of USP18 by SKP2 ( Tokarz et al ., 2004 ) and is critical to ensure negative regulation of IFN-alpha / beta immunity by stabilizing USP18 ( Zhang et al ., 2015 ) ."
32039148
reach
"ISG15 was shown to bind to and prevent USP18 degradation mediated by S-phase kinase-associated protein 2 (SKP2)-dependent ubiquitylation ."
29769653
reach
"We therefore analysed the impact of ISG15 on SKP2 mediated USP18 degradation."
25307056
reach
"This binding prevents the SKP2 mediated degradation of USP18, and thus is critical for the accumulation of USP18 and the appropriate regulation of IFN-alpha and beta signalling."
27193971
reach
"ISG15 was shown to bind to and prevent uSP18 degradation mediated by S-phase kinase-associated protein 2 (SKP2)-dependent ubiquitylation 4,114 ."
29769653
reach
"In humans, binding of free ISG15 prevents proteasomal degradation of USP18 by SKP2 (Tokarz et al., 2004) and is critical to ensure negative regulation of IFN-α/β immunity by stabilizing USP18 (Zhang et al., 2015)."
32039148