IndraLab

Statements

SKP2 inhibits USP18. 7 / 7
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"ISG15 was shown to bind to and prevent USP18 degradation mediated by S-phase kinase-associated protein 2 (SKP2)-dependent ubiquitylation ."
29769653
reach
"The association of ISG15 with USP18 interrupts the interaction of USP18 with S-phase kinase-associated protein 2 (SKP2), inhibiting the proteasomal degradation of USP18, which is essential for negative feedback regulation of IFN signaling and prevention of autoinflammation ."
36319753
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"In humans, binding of free ISG15 prevents proteasomal degradation of USP18 by SKP2 (Tokarz et al., 2004) and is critical to ensure negative regulation of IFN-α/β immunity by stabilizing USP18 (Zhang et al., 2015)."
32039148
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"We therefore analysed the impact of ISG15 on SKP2 mediated USP18 degradation."
25307056
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"This binding prevents the SKP2 mediated degradation of USP18, and thus is critical for the accumulation of USP18 and the appropriate regulation of IFN-alpha and beta signalling."
27193971
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"Interestingly, the stability of USP18 decreases in the absence of intracellular ISG15, and this is attributed to inhibition of USP18 degradation by SKP2, which targets USP18 to the CRL SKP2 Ub-ligase [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29102683
eidos
"In humans , binding of free ISG15 prevents proteasomal degradation of USP18 by SKP2 ( Tokarz et al ., 2004 ) and is critical to ensure negative regulation of IFN-alpha / beta immunity by stabilizing USP18 ( Zhang et al ., 2015 ) ."
32039148