IndraLab

Statements

ATXN3 activates VCP. 3 / 3
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"It is speculated that ataxin-3 acts as an ubiquitin chain editing enzyme, promoting Cdc48 associated de-ubiquitylation to facilitate transfer of misfolded proteins from Cdc48 to the proteasome [105] ."
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"Various ataxin-3 protein domains contribute to its toxicity, including the valosin-containing protein (VCP)-binding motif (VBM)."
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"In this scenario, ATX3 promotes sufficient p97‐dependent extraction of RNF8 in a classical ERAD‐like manner (Wang et al, 2006; Zhong & Pittman, 2006)."
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