IndraLab

Statements

Lactate inhibits IFNB1. 7 / 7
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"Thus, IFN-β conditioning prior to infection decreases macrophage lactate production and histone lactylation."
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"In addition, administration of sodium lactate in mice reduced production of IFN-b."
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"Lactate supplementation reversed the effect of IFN-β conditioning up to 48 hpi (Figure 5K)."
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"Secondly, a dual luciferase reporter gene assay result showed that lactate inhibits the IFN-β promoter in the presence of MDA5, RIG-I, and MAVS, but not in TBK1 and IRF3 ( Fig. 5 C)."
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"Lactate induced HBV replication and inhibited IFN-beta expression ; however , this effect was markedly reduced by an MCT1 knockdown ( Supplementary Fig. 6f-h ) , suggesting that lactate transport into cells is essential for HBV-mediated immune escape ."
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"Secondly, a dual luciferase reporter gene assay result showed that lactate inhibits the IFN-β promoter in the presence of MDA5, RIG-I, and MAVS, but not in TBK1 and IRF3 ( Fig. 5 C)."
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"Moreover, lactate addition in Ldha -/- macrophage consistently reduced IFN-beta production (XREF_FIG)."
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