IndraLab

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Minocycline inhibits NLRP3. 16 / 16
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"In this study, we investigated the potential of minocycline to inhibit NLRP3-triggered inflammatory responses in a laboratory setting."
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"NLRP3 can be selectively blocked by concentrated extracellular K , MCC950, ketogenic diet, glyburide, and minocycline (Muñoz-Planillo et al., 2013; Wallisch et al., 2017)."
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"Moreover, the upregulated Tnf-α and Nlrp3 gene transcripts were only moderately suppressed by minocycline (Tnf-α: fold = 0.469, FDR = 0.275; Nlrp3: fold = 0.79, FDR = 5.55E-12)."
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"Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke."
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"Minocycline suppressed NLRP3/Casapase-1 pathway activation in LPS-treated BV2 cells."
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"Prior evidence has indicated that NLRP3 could be selectively blocked by concentrated extracellular K+, glyburide, MCC950, minocycline and KD [78,79]."
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"Minocycline treatment inactivates NLRP3 inflammasome, blocks pyroptosis in oligodendrocytes, and ameliorates depression in rats.Glutamate is an excitatory neurotransmitter."
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"Furthermore, the minocycline mediated NLRP3 inflammasome inhibition and its subsequent therapeutic effect in DN was absent in diabetic Nrf2 KO mice, thereby implicating Nrf2 protection at the level of the inflammasome."
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"Pretreatment with minocycline prevented the activation of microglia by attenuating NLRP3 inflammasome signaling, thereby ameliorating ischemia-induced brain damage (Lu et al., 2016)."
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"These results demonstrated that CGRP and minocycline could inhibit microglial activation and NLRP3/caspase-1 pathway in the spinal cord, and relieved hyperalgesia in DLBP rats.4 Discussion."
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"Minocycline inhibited the NLRP3/Casapase-1 pathway activation in the hippocampus of LPS-treated mice."
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"Minocycline, an anti-inflammatory tetracycline-class drug, reduces the accumulation of Aβ and attenuates microglia activation by inhibiting the NLRP3 inflammasome [267]."
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"Concomitantly, other known antibiotics, such as minocycline and rifampicin, aside from inhibiting the NLRP3 pathway, may facilitate the removal of senescent cells [184, 283]."
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"Meanwhile, we showed that minocycline prevented the activation of microglias and attenuated NLRP3 inflammasome signaling after tMCAO injury."
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"Accordingly, minocycline mediated Nlrp3 inflammasome inhibition and amelioration of dNP are abolished in diabetic Nrf2 -/- mice."
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"Furthermore, we found that the pretreatment of minocycline significantly inhibited signal 1 and signal 2 of NLRP3 inflammasome activation in BV2 cells."
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