IndraLab

Statements

Minocycline inhibits NLRP3. 8 / 8
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"However, the findings were inconsistent as signal-1 dependent NLRP3 and pro-IL-1β but not pro-caspase-1 production was inhibited by minocycline [26]."
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"Moreover, the upregulated Tnf-α and Nlrp3 gene transcripts were only moderately suppressed by minocycline (Tnf-α: fold = 0.469, FDR = 0.275; Nlrp3: fold = 0.79, FDR = 5.55E-12)."
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"Concomitantly, other known antibiotics, such as minocycline and rifampicin, aside from inhibiting the NLRP3 pathway, may facilitate the removal of senescent cells [184, 283]."
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"Meanwhile, we showed that minocycline prevented the activation of microglias and attenuated NLRP3 inflammasome signaling after tMCAO injury."
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"Accordingly, minocycline mediated Nlrp3 inflammasome inhibition and amelioration of dNP are abolished in diabetic Nrf2 -/- mice."
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"Furthermore, we found that the pretreatment of minocycline significantly inhibited signal 1 and signal 2 of NLRP3 inflammasome activation in BV2 cells."
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"Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke."
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"Furthermore, the minocycline mediated NLRP3 inflammasome inhibition and its subsequent therapeutic effect in DN was absent in diabetic Nrf2 KO mice, thereby implicating Nrf2 protection at the level of the inflammasome."
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