IndraLab

Statements

FZD binds USP8. 3 / 3
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"Mechanistically, TMEM79 forms a complex with FZD and USP8 and inhibits USP8 deubiquitination of FZD during biogenesis, thereby promoting trafficking of ubiquitinated FZD from ER to the lysosome for destruction ( xref )."
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sparser
"FZD-USP8 interaction was unaffected by TMEM79 overexpression ( xref ), ruling out a scenario that TMEM79 competes with FZD for USP8-binding to achieve inhibition of FZD deubiquitination by USP8."
32924931
sparser
"We found that FZD-USP8 interaction was observed in TMEM79 KO cells ( xref ) and thus is not mediated by TMEM79."
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