IndraLab

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"Furthermore, silencing of USP4 significantly rescued FBXO3- or FBXO3 -induced cell migration in MDA-MB-231 cells (Figs 3L, S2E, and S2F)."
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"USP4 has previously been confirmed to target TRAF2 and TRAF6 for deubiquitination and it has been established that USP4 inhibits TNFalpha induced cancer cell migration 35."
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"AKT induced breast cancer cell migration could be inhibited by depletion of USP4 (Zhang et al., 2012)."
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"However, in breast cancer, USP4 was also recognized as a tumour suppressor for its up-regulatory effect on programmed cell death 4 (PDCD4) to restrain tumour growth.20 Moreover, USP4 was able to target TRAF2 and TRAF6 for deubiquitination and thereafter inhibited TNFalpha induced cancer cell migration.34 In the present study, we proved that USP4 expression was drastically increased in melanoma."
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"USP4 can inhibit NF-κB activation through deubiquitination of TRAF2 and TRAF6, thereby promoting cell migration and invasion in lung cancer (46)."
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"Moreover, AKT induced breast cancer cell migration was inhibited by USP4 depletion and TbetaRI kinase inhibition."
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"Also, the in vitro wound healing assay for cell migration showed that low expression of USP4 reduced cell migration."
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"USP4 can detach the K63-linked polyubiquitin chains from all these proteins to downregulate the p65/p50 activity in multiple cell lines and inhibit cell migration of pulmonary carcinoma (22,38,39)."
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