IndraLab

Statements

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"Intact BAP1 catalytic activity could increase aerobic glycolysis and lactate secretion and reduce mitochondrial respiration and ATP production [49]."
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"In non-tumoral cells, reduced BAP1 levels induced the Warburg effect, a shift of cell metabolism from oxidative phosphorylation (Krebs cycle) to aerobic glycolysis, originally identified as typical of cancer cells."
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"Moreover, BAP1 fibroblasts enhance aerobic glycolysis and lactate secretion, but reduce mitochondrial respiration and ATP production, when compared with wild-type BAP1."
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