IndraLab

Statements

reach
"9 Protonation of hydroxychloroquine prevents the breakdown of heme creating a toxic environment and the parasite is killed through cell lysis."
23777781
reach
"In addition, HCQ and CQ inhibit the bio-crystallization of the toxic heme molecule (from the hemoglobin derived from the host blood) to nontoxic hemozoin within the parasite, and high accumulation of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33360293
reach
"Chloroquine and its derivative hydroxychloroquine inhibit the heme polymerase in malarial trophozoites, preventing the conversion of heme to hemozoin."
| PMC
reach
"Chloroquine and its derivative Hydroxychloroquine inhibit the heme polymerase in malarial trophozoites, resisting the conversion of heme to hemozoin."
32437797