IndraLab

Statements

AKT phosphorylates NOS3 at position 1177. 3 / 3
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"This activation of endothelial Akt has been shown to stimulate phosphorylation of eNOS at serine residue 1177, known to be an important regulatory mechanism leading to eNOS activation."
22431312
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"We tested the hypothesis that impaired nitric oxide (NO)-mediated, endothelium dependent dilation in aged soleus muscle feed arteries (SFA) is due to an age related decline in the potential for PI3-kinase (PI3K)/protein kinase B (Akt)-dependent phosphorylation of endothelial NO synthase (eNOS) on serine residue 1177 (p-eNOS (ser1177))."
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"Akt kinase, which can phosphorylate eNOS Ser (1177), was also decreased by hypoxia, regarding both total protein content and the phosphorylated (active) form."
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