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STAMBPL1 activates HIF1. 7 / 7
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"In summary, STAMBPL1 promoted TNBC angiogenesis by activating the GRHL3/HIF1α/VEGFA pathway via interacting with FOXO1 in a non-enzymatic manner."
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"In this study, we discovered that STAMBPL1 promotes angiogenesis in TNBC by activating the HIF1α/VEGFA pathway independently of its enzymatic activity."
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"Under normoxic conditions, both STAMBPL1 and its enzymatically mutated variant (E292A) can upregulate the protein expression of HIF1α (Figure 1F)."
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"To elucidate how STAMBPL1 upregulates HIF1α, we examined the transcription levels of HIF1A when STAMBPL1 was knocking down under hypoxia."
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"These findings suggest that STAMBPL1 activates the HIF1α/VEGFA axis in TNBC cells, leading to enhanced abilities of HUVECs through a paracrine pathway."
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"These findings suggest that STAMBPL1 activates the HIF1α/VEGFA axis by upregulating GRHL3."
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"Our study reveals for the first time that GRHL3 promotes transcriptional activity by binding to the promoter of the HIF1A gene.In this study, we utilized two TNBC cell lines, HCC1806 and HCC1937, along with human primary umbilical vein endothelial cells (HUVECs) and a nude mouse breast orthotopic transplantation tumor model to investigate the regulatory mechanism by which STAMBPL1 activates the GRHL3/HIF1α/VEGFA signaling pathway through its interaction with FOXO1, thereby promoting angiogenesis in TNBC."
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