IndraLab

Statements

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"NFATc2 also plays a crucial role peripherally, as the loss of the deubiquitinating enzyme USP15 indirectly inhibits NFATc2 degradation, promoting T cell activation [51]."
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"USP15 negatively regulates T cell activation by stabilizing E3 ubiquitin ligase MDM2 that promotes ubiquitin dependent degradation of NFATc2."
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"Additionally, Qiang Zou et al. reported that USP15 negatively regulated T cell activation by targeting the degradation of NFATC2 [ 15 ]."
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"The above researchers previously found that USP15 could negatively regulate naive CD4 T cell activation and differentiation into the IFN-γ-producing Th1 cells."
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