IndraLab

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BAP1 inhibits cell death. 13 / 13
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"Arabidopsis C2 domain proteins, BAP1, and its homologue BAP2, negatively regulate biotic and abiotic cell death."
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"Changes in mitochondrial permeability are required for the activation of the apoptotic process and the loss of BAP1 protects the cells from caspase-induced cell death as a consequence of IP3R3 level reduction and Ca2 + signalling decrease [45]."
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"Here we show that BAP1 inhibits cell death induced by unresolved metabolic stress."
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"Here we show that BAP1 inhibits cell death induced by unresolved metabolic stress."
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"He et al. showed that Bap1 knockout in mouse embryonic stem (ES) cells, fibroblasts, and keratinocytes caused cell death through the intrinsic apoptosis pathway (1), which is mediated by Bax/Bak oligomerization."
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"Functional studies were not conducted because cells from these patients were not available.Our findings revealed that both BAP1 and BARD1 inactivate similar pathways: DNA repair, calcium signaling, and cell death, although through different mechanisms."
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"BAP1 depletion, however, triggers cell death in many cell types, which could seem paradoxical considering its tumor suppressor function."
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"The group of flg22 induced MPK4 dependent genes encode important regulators of plant defence such as the cell death inhibitor BAP1 [XREF_BIBR], the calcium dependent protein kinase CPK5 [XREF_BIBR], the exocyst complex subunit EXO70B2 [XREF_BIBR], the cyclic nucleotide gated ion channel CNGC11 [XREF_BIBR] or the BAK1 like receptor kinase BKK1 and SERK4 [XREF_BIBR]."
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"Arabidopsis C2 domain proteins, BAP1 and its homologue BAP2, negatively regulate biotic and abiotic cell death [12,13] ."
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"Thus, BAP1 might suppress tumorigenesis by facilitating tumor cell death by activation of both these pathways."
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"XREF_BIBR reported that BAP1 overexpression in the BAP1-null NCI-H226 human non-small-cell lung cancer cell line suppressed growth in DUB activity- and nuclear localization dependent manners by accelerating the cell cycle G1/S transition and inducing cell death."
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"The powerful activity of heterozygous germline BAP1 mutations to facilitate asbestos induced transformation and cause mesothelioma has been linked to the alterations in the mechanisms that regulate DNA repair and cell death caused by decreased BAP1 protein levels."
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"For instance, tumor suppressor p53 and BAP1 could suppress tumor development by promoting either apoptotic or ferroptotic cell death."
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