IndraLab

Statements

COPS5 increases the amount of STAT3. 6 / 6
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"JAB1 knockdown decreased unphosphorylated STAT3 DNA binding activity, but tends to increase nuclear STAT3 expression level."
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"In order to delineate whether Stat3 regulates Jab1 transcription, we performed a luciferase reporter assay with 5 ' deletion analysis of the human Jab1 promoter."
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"Moreover, the overexpression of COPS5 increased p-STAT3 level, while PVT1 knockdown or TRIM24 knockout caused a dramatic decrease in COPS5 overexpression-increased p-STAT3 level (Figure 8G)."
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"Besides the findings in this study, it is quite likely that JAB1 positively regulates β-catenin/TCF4 and STAT3-dependent transcription in human CRC cells."
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"Likewise, Jab1/CSN5 silencing decreases the expression of STAT3 target genes ."
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"Jab1/CSN5 knockdown significantly decreased the expression levels of Stat3 target genes in human colon cancer cell ( Nishimoto et al., 2013 )."
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