IndraLab

Statements


MYC activates COPS6. 3 / 3
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"CSN6 increase Myc stability by reducing Myc ubiquitination."

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"A recent study also demonstrated that CSN6 contributed to carcinogenesis by positive regulation of Myc stability."

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"As expected, Myc mediated transcriptional activation target CDK4 and Myc mediated transcriptional repression targets p27Kip1 and p21Cip1 were deregulated in Emicro-Myc and Csn6 +/- lymphomas compared to Emicro-Myc and Csn6 +/+ lymphomas (XREF_FIG)."