IndraLab

Statements

STAMBP inhibits NLRP7. 3 / 3
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"STAMBP may increase NALP7 (NACHT, LRR and PYD domains-containing protein 7) abundance by inhibiting the trafficking of the inflammasome NALP7 to lysosomes and preventing the lysosomal degradation of NALP7 (Bednash et al., 2017)."
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"With TLR ligation, the deubiquitinase enzyme, STAM binding protein (STAMBP) impedes NALP7 trafficking to lysosomes to increase NALP7 abundance."
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"The first evidence between NLRP7 and ubiquitin pathway was published in 2017, where Bednash and colleagues described that the DUB STAM-binding protein (STAMBP) was able to inhibit NLRP7 activity through deubiquitylation of poly-ubiquitin chains conjugated to Lys288 and Lys290 residues (Bednash et al., 2017)."
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