IndraLab

Statements


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"Nuclear localized USP15 interacts with pre-mRNA processing factor 19 (PRPF19) to increase CD44 RNA alternative splicing activating β-catenin and enhancing cancer stemness."

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"Our co-IP data showed that stably overexpressing ABHD11-AS1 in non-transformed human bronchial epithelial cells drastically increased the interaction of USP15 with splicing factor PRPF19 (Pre-mRNA Processing Factor 19) ( xref )."

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"Since manipulating ABHD11-AS1 or SART3 displayed dramatic and consistent effects on the interaction between USP15 and PRPF19 ( xref to xref ), we further determined nuclear level of PRPF19 and the effects of manipulating ABHD11-AS1, SART3 or USP15 expression on nuclear PRPF19 levels."

sparser
"ABHD11-AS1 and SART3 increase the interaction of USP15 with RNA splicing factor PRPF19."