IndraLab

Statements

FANCI inhibits USP1. 3 / 3
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"Conversely, FANCI phosphorylation reportedly impedes activity of the cognate deubiquitinating enzyme USP1 35, thus favouring the ubiquitinated state."
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"Then FANCI phosphorylation by ATR probably limits access of USP1 (but not the core complex), leading to mono-ubiquitinated FANCD2 and FANCI complex with a higher affinity to damaged chromatin."
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"This idea is fascinating, and suggests that FANCI phosphorylation is actually functioning to suppress USP1 de-ubiquitinase access rather than triggering activation of the E3 ligase FANCL.Interestingly[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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