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Pyraclofos activates CACNA1C. 8 / 8
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"Subsequent work revealed that blocking high voltage-activated CaV1.2 channels at −40 mV where its window current is modest had little impact on STOC production (Knot & Nelson, 1998; Nikitina et al. 2007; Abd El-Rahman et al. 2013)."
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"GH3 cells also express, as a component of the high voltage-activated Ca 2+ currents the Cav1.2 channel ( Meza et al., 1994; Liévano et al., 1994 )."
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"Further, chronic Triumeq exposure in vivo significantly enhanced mRNA expression of low voltage-activated (LVA) L-type Ca 2+ channels (Ca v 1.3 L-channels), while changes in high voltage-activated (HVA) Cav1.2 L-channels were not observed."
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"Acknowledging this implicit relationship, initial work defining the trigger focused interest on high voltage-activated CaV1.2, the dominant conductance setting cytosolic [Ca2+] in vascular smooth muscle (Knot & Nelson, 1998)."
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"An increase in the intravascular pressure can depolarize smooth muscle cell sarcolemma and promote opening of voltage-activated CaV1.2 channels [19] ."
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"Accordingly, the kinetics of voltage-driven Cav1.2 opening/closure reverberate the kinetics of RyR2 opening/closure."
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"L-type Ca channels (LTCCs) are macromolecular complexes consisting of the α1C subunit, which is the pore-forming subunit containing the voltage sensor, and auxiliary subunits (β2b, α2δ, γ), which modulate biophysical and trafficking properties of the cardiac Cav1.2 channel [2]."
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"Interestingly, a reciprocal interaction between voltage-activated Cav1.2 channels and store-operated Ca 2+ channels, mediated by STIM1, has been reported [ xref , xref ]."
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