IndraLab

Statements

Ticagrelor inhibits NLRP3. 10 / 10
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"Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y"
32523112
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"Therefore, targeting these mechanisms may reduce MIRI-induced ALI, but further analysis is necessary to determine the underlying molecular mechanisms.Our findings also confirmed previous reports that ticagrelor attenuated NLRP3 activation in various animal models."
38188139
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"More importantly, Huang et al. found that ticagrelor inhibited the activation of NLRP3 inflammasome, suggesting that ticagrelor might be a potential therapeutic agent for NLRP3 associated diseases (su[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114201
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"In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on the P2Y 12 signaling pathway."
32523112
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"Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome."
32523112
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"Both ticagrelor and rosuvastatin reduced postinfarction activation of NLRP3 inflammasome [136]."
34123416
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"Furthermore, ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory diseases independent of the P2Y signaling pathway (30, 31)."
36684601
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"Pre-treatment with the high-dose of ticagrelor suppressed MIRI-induced upregulation of NLRP3 (0.46-fold, P < 0.05), ASC (0.64-fold, P < 0.01), and Cleaved caspase-1 (0.80-fold, P < 0.01)."
38188139
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"Ticagrelor, a P2Y12 receptor antagonist, and dapagliflozin, a sodium-glucose-cotransporter-2 inhibitor, suppress the activation of the NLRP3 inflammasome."
32335797
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"Both dapagliflozin and ticagrelor attenuated the progression of diabetic cardiomyopathy, the activation of the NLRP3 inflammasome, and fibrosis in BTBR mice with additive effects of the combination."
32335797