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"Conversely, some studies also suggest USP38 as a tumor suppressor, such as USP38 promotes nonhomologous end joining repair in kidney clear cell carcinoma cancer by deubiquitinating HDAC1 to modulate its activity, maintaining genome stability and regulating cancer cells' response to genotoxic insults (15); USP38 inhibits tumor stemness in colorectal cancer by mediating K63 deubiquitination of HDAC3 (16); USP38 suppresses cell proliferation and migration by downregulating HMX3 ubiquitination in colorectal cancer (17); METTL14 inhibits bladder cancer cell migration and invasion by stabilizing USP38 (18)."