IndraLab

Statements


USP9X decreases the amount of VHL. 3 / 3
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"As knockdown of USP9X in HEK293T cells significantly increased pVHL levels, both mRNA levels and protein half-life of pVHL were evaluated in HEK293T cells to further investigate the mechanism by which USP9X regulates pVHL."

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"This study shows that inhibition of USP9X function by either shRNA or a chemical inhibitor significantly enhances pVHL levels and suppresses tumor cell proliferation."

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"USP9X negatively regulates pVHL levels and consequently protects HIF and NF-kappaB activity."