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PKA activates KCNQ1. 9 / 11
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"For instance, whereas PKA-mediated phosphorylation increases the currents in Kv7.1, Kv7.2, and Kv7.3—members of the KCNQ family—tyrosine phosphorylation of these channels downregulates their expression in neurons [10]."
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"Yazawa and Kameyama [XREF_BIBR] found that both isoprenaline (a beta-adrenergic receptor agonist) and PKA increase the amplitude of KCNQ1 and KCNE1 currents in guinea pig cardiomyocytes."
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"Due to evidence that PKA mediates in the nicotine effect (Figure  xref ), we also addressed the role of the PKA‐activated potassium channel KCNQ1."
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"Furthermore, whether PKA activation alters the voltage sensor movement and/or the VSD-PD coupling has not been tested yet, which may help to understand how PKA activation modulates the KCNQ1 and KCNE1 function by beta-adrenergic simulation."
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"Although PKA activation of Kv7.1 following β adrenergic stimulation can increase I Ks , chronic β adrenergic stimulation downregulates the I Ks response ( xref )."
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"Another remaining question is whether and how the mechanism through which KCNE1 selectively modulates the intermediate-open and activated-open states underlies the changes in channel modulation by PKA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Many of the PKA insensitive LQT1-linked mutations were found to localize to cytoplasmic loops and, similar to A341V-Kv7.1, these PKA insensitive mutations appear to confer an increased risk for life-threatening events in people.Several KCNQ1 mutations can also cause a “concealed LQT1” phenotype [52,66,102]."
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"All these results suggest that the KCNQ1 sensitivity to PIP 2 is modulated by PKA."
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"That is, the mutations in C-loop could blunt PKA-mediated activation of channel activity, KCNQ1 c.749T > C, which is also located in the C-loop (S4-5 link), might lead to the maladaptation of cardiomyocyte to the rapid heart rate during repolarization phase."
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