IndraLab

Statements

PKA activates KCNQ1. 5 / 7
| 3 2
sparser
"Although PKA activation of Kv7.1 following β adrenergic stimulation can increase I Ks , chronic β adrenergic stimulation downregulates the I Ks response ( xref )."
32695022
reach
"Yazawa and Kameyama [XREF_BIBR] found that both isoprenaline (a beta-adrenergic receptor agonist) and PKA increase the amplitude of KCNQ1 and KCNE1 currents in guinea pig cardiomyocytes."
33322401
reach
"All these results suggest that the KCNQ1 sensitivity to PIP 2 is modulated by PKA."
22787448
sparser
"Due to evidence that PKA mediates in the nicotine effect (Figure  xref ), we also addressed the role of the PKA‐activated potassium channel KCNQ1."
32959891
reach
"Furthermore, whether PKA activation alters the voltage sensor movement and/or the VSD-PD coupling has not been tested yet, which may help to understand how PKA activation modulates the KCNQ1 and KCNE1 function by beta-adrenergic simulation."
33322401