IndraLab

Statements

BAP1 inhibits Proteasome. 3 / 3
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"Following depletion of BAP1 for 72 h, treatment with MG132 for 6 h led to a substantial rescue of BRCA1 expression in MSTO-211H and NCI-H2452 cells indicating that BAP1 inhibits the proteasome-mediated degradation of BRCA1 (Fig. 1B)."
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"Depletion of BAP1 protein induced proteasome-mediated degradation of BRCA1 in mesothelioma cells while loss of BAP1 correlated with BRCA1 loss in mesothelioma patient tumour samples."
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"Furthermore, BAP1 protein appears to inhibit FOXO3a degradation via the proteasome-dependent pathway, thereby preserving the activity and stability of the FOXO3a protein."
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