IndraLab

Statements

reach
"Furthermore, EGCG inhibited the activation of caspase-1 in HMC-1 cells."
21833768
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"177 In one study, EGCG resulted in NFkappaB inhibition, which was associated with reduced melanoma cell interleukin-1beta (IL-1beta) secretion, downregulation of the inflammasome component, nuclear localization leucine-rich-repeat protein 1 (NLRP1), and decreased caspase-1 activation."
25597784
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"We found that EGCG inhibits caspase-1 activation and IL-1beta secretion by suppressing NLRP3 inflammasome activation in mouse bone marrow derived macrophages (BMDMs)."
33524801
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"In this study, we found that NO treatment resulted in caspase-1 activation and IL-1beta production, while EGCG inhibited the observed NO induced increase in IL-1beta production and caspase-1 activation, suggesting that the caspase-1 pathway is a potential therapeutic target for preventing NO induced ototoxic damage."
23028481
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"Since inflammasomes are involved in IL-1beta secretion, we investigated whether IL-1beta suppression was mediated by inflammasomes, and found that EGCG treatment led to downregulation of the inflammasome component, NLRP1, and reduced caspase-1 activation."
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