IndraLab

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USP15 increases the amount of YY1. 3 / 3
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"To determine if ectopic USP15 and UbV expression could also alter YY1 transcription and subsequently contribute to changes in YY1 protein expression, we transfected 293T with pNL4-3 and with or without pUSP15-Myc or pFlag-UbV15.1, isolated total RNA, and performed qRT-PCR for the YY1 mRNA level."
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"The results showed that neither ectopic USP15 expression nor UbV expression resulted in any apparent changes in YY1 mRNA expression when compared to the control or to each other ( Figure 7 ), indicating that changes of YY1 protein expression by ectopic USP15 and UbV expression are unlikely to occur at the transcription level, and rather at the post-translational level.3.6 Ectopic USP15 and UbV expression altered YY1 ubiquitination."
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"Direct WB of whole cell lysates confirmed USP15, UbV expression, and increased YY1 protein expression by exogenous USP15 and decreased YY1 protein expression by UbV15.1 even in the presence of Carfilzomib treatment ( Figure 8A )."
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