IndraLab

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COPS5 binds UCHL3. 18 / 18
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"Thus, we demonstrate that UCHL3 regulates Cullin1 neddylation dependently on COPS5.To further understand the relationship of UCHL3 and COPS5, we analyzed the interaction between UCHL3 and COPS5."
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"Furthermore, we found that endogenous UCHL3 can also interact with endogenous COPS5."
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"Given that we demonstrated that UCHL3 promoted activation of IFN signaling, we observed whether IFN-I could affect the interaction between UCHL3 and COPS5."
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"The result showed that IFNalpha promoted the binding of UCHL3 to COPS5 during the early stage of IFNalpha treatment, which is consistent with the effect of UCHL3 on TYK2 phosphorylation during the ear[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We demonstrate that UCHL3 physically interacts with COPS5, and increases COPS5 levels and protein stability by deubiquitinating COPS5."
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"Furthermore, we found that endogenous UCHL3 can also interact with endogenous COPS5 ( Fig. 4 B)."
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"Given that we demonstrated that UCHL3 promoted activation of IFN signaling, we observed whether IFN-I could affect the interaction between UCHL3 and COPS5."
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"Next, we find that UCHL3 physically interacts with COPS5, and upregulates COPS5 levels and protein stability by deubiquitinating COPS5."
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"The result showed that IFNα promoted the binding of UCHL3 to COPS5 during the early stage of IFNα treatment ( Fig. 4 B), which is consistent with the effect of UCHL3 on TYK2 phosphorylation during the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Given that UCHL3 interacts with COPS5 in IFN signaling and UCHL3 is a deubiquitinase, we question whether UCHL3 promotes COPS5 deubiquitination."
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"These results imply that UCHL3 physically interacts with COPS5 and deubiquitinates COPS5."
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No evidence text available
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No evidence text available
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"Next, we find that UCHL3 physically interacts with COPS5, and upregulates COPS5 levels and protein stability by deubiquitinating COPS5."
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"These results imply that UCHL3 physically interacts with COPS5 and deubiquitinates COPS5.Given that UCHL3 can deubiquitinate COPS5, we speculate that UCHL3 could affect cellular levels of COPS5."
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sparser
"To further understand the relationship of UCHL3 and COPS5, we analyzed the interaction between UCHL3 and COPS5."
28583475
reach
"We demonstrate that UCHL3 physically interacts with COPS5, and increases COPS5 levels and protein stability by deubiquitinating COPS5."
28583475
biogrid
No evidence text available
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