IndraLab

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UCHL3 activates MES. 2 / 2
| 2
reach
"At the molecular level, under IR exposure UCHL3 knockdown reduced the protein expression of well-known MES GSC markers (CD44, TAZ, etc.), and POLD4 overexpression restored the expression of these markers (Fig. 6H)."
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reach
"For the HDR and NHEJ reporter assay, silencing UCHL3 reduced HDR and NHEJ efficiency in MES GSCs followed by IR, and ectopic expression of POLD4 overcame the inhibitory effects of UCHL3 depletion on MES GSCs (Fig. 6F, G and Fig. S7B, C)."
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