IndraLab

Statements


TNF activates USP7. 3 / 3
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"Furthermore, the interaction between endogenous HSCARG and USP7 in cells treated with or without TNFalpha was investigated by co-IP assay."

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"None of the recombinant TNF proteins were cytotoxic, and TNF-alpha significantly increased both USP7 and USP13 confluence, indicating that soluble TNF-alpha enhances brain tumour cell growth (Fig. 4F and G)."

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"Nonetheless, a minimum of two siRNA molecules led to increased levels of nuclear NF-kappaB in A549 cells depleted of A20, USP7, USP49, USP54, or FBXO36 and treated with TNF for 120min."