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VCP inhibits ATXN3. 2 / 2

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"The same study also showed that recombinant VCP stimulates fibrillogenesis and aggregation of recombinant, pathogenic ataxin-3 in a dose dependent manner in reconstituted systems, but only up to a point; molar excess VCP suppresses ataxin-3 fibrillogenesis."

29704548

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"Nevertheless, interaction with hHR23A could change the affinity of ataxin-3 for VCP and p97 and thus impair VCP and p97 induced activation of ataxin-3."

22970133

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VCP inhibits ATXN3. 2 / 2

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