IndraLab

Statements

Terbinafine activates KCNH2. 5 / 5
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"Taken together, these data support a model where terbinafine treatment induces a pulse of Erg1 synthesis essential for survival, which requires Get3 for high-fidelity and efficient targeting to the ER."
35587358
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"Importantly, the increase in Erg1 abundance caused by terbinafine addition was hampered by chelating iron (Figure 3, +BPS + TER), although the levels of ERG1 mRNA and protein remained higher than in strains grown in SC medium."
35837730
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"Synergy with geldanamycin was also observed between the allylamine terbinafine (FIC 90 = 0.25), which targets Erg1, and the morpholine fenpropimorph (FIC 90 = 0.016), which targets Erg24 and Erg2 (XREF_FIG)."
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"The manipulation markedly increased the terbinafine tolerance of the WT strain, confirming the functionality of GFP–Erg1 and an increased capacity for converting squalene into squalene epoxide in this scenario."
35587358
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"Terbinafine targets ERG1, which is the upstream gene for ERG11, the target for posaconazole."
27415801