IndraLab

Statements

OTUD3 deubiquitinates TP53. 6 / 6
| 6
reach
"OTUD3 likely deubiquitinates p53 to counteract the action of the E3 ubiquitin ligase Mdm2."
32571254
reach
"OTUD3 deubiquitinates p53."
32571254
reach
"As indicated in Fig. 5a, a high level of ubiquitinated p53 was found in the MCF7 and DU4475 cells transfected with Mdm2 (lane 2); however, p53 ubiquitination was significantly abrogated by OTUD3 expression (comparison of lanes 3 and 2)."
32571254
reach
"As OTUD3 is a deubiquitinase, we examined whether OTUD3 deubiquitinates p53."
32571254
reach
"Collectively, these data demonstrate that OTUD3 negatively regulates p53 ubiquitination in breast cancer cells and plays an important role in the balance between p53 ubiquitination and deubiquitination."
32571254
reach
"Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells."
32571254