IndraLab

Statements

USP2 inhibits Cyclin. 3 / 3
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"The ubiquitin dependent proteolysis of cyclin D1 is antagonized by the deubiquitinating enzyme USP2, thus increasing cyclin D1 half-life."
30853938
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"Based on our results, it is highly likely that USP-2 suppression by adiponectin enhanced proteasomal activity, thereby increasing cyclin D1 degradation, whereas enhancement in USP-2 expression by lept[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26033248
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"These data demonstrate that inactivation of USP2 downregulates the levels of endogenous cyclin D1 and suppresses cell growth by delaying G1/S progression."
19917254