IndraLab

Statements


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"Along with the upregulation of phosphorylated AMPKalpha and ACCalpha, metformin at 1.5 and 3mM inactivated NF-kappaB signalling components (p65 and IkappaBalpha) and the inflammatory genes (TNFA, IL6, IL1B and COX-2) which were activated by BHBA."

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"In addition, metformin suppressed the transcription activity of NF-kappaB by inhibiting the degradation of IkappaBalpha."

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"Metformin inhibited the NFkappaB signaling components IKKbeta, IKKalpha, NFkappaB, IkappaBalpha (A) and p-IKKalpha and beta, p-NFkappaB, p-IkappaBalpha (B)."