IndraLab

Statements

CYLD activates Wnt. 4 / 4
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reach
"Therefore, the activity of this DUB should stimulate rather than attenuate the signalling activity of Dvl, which means that the observed downregulation of Wnt signalling by CYLD XREF_BIBR can not be explained by its effect on Dvl polymerization."
25907794
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"Other investigations reveal that inactivated expression of CYLD strongly promotes the Wnt signaling and is associated with a poor prognosis in multiple myelomas [13] and leukemia/lymphoma [11,14]."
37549179
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"Loss of function of CYLD, due to either mutation or deletion, can lead to dysregulated NF-κB and Wnt activity, promoting cell survival and proliferation.75 Studies have shown that CYLD mutations are associated with advanced stages of MM and may contribute to therapeutic resistance.75,123DIS3 is an RNA exosome component implicated in RNA processing and degradation."
39723112
reach
"The DIX domain is ubiquitinated in vivo at multiple lysines, which can be antagonized by various deubiquitinases (DUBs) including the CYLD tumour suppressor that attenuates Wnt signalling."
25907794