IndraLab

Statements

CYLD activates Wnt. 3 / 3
| 3
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"Therefore, the activity of this DUB should stimulate rather than attenuate the signalling activity of Dvl, which means that the observed downregulation of Wnt signalling by CYLD XREF_BIBR can not be explained by its effect on Dvl polymerization."
25907794
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"Loss of the tumor suppressor CYLD enhances Wnt and beta-catenin signaling through K63 linked ubiquitination of Dvl."
20227366
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"The DIX domain is ubiquitinated in vivo at multiple lysines, which can be antagonized by various deubiquitinases (DUBs) including the CYLD tumour suppressor that attenuates Wnt signalling."
25907794