IndraLab

Statements

PSMD14 activates cell growth. 8 / 9
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"PSMD14 is strongly associated with poor prognosis in lung adenocarcinoma (LUAD), and PSMD14 knockdown significantly inhibits cell growth and affects lung cancer progression by modulating p21 stability, leading to G1-phase arrest and cellular senescence (26)."
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"Further, knockdown of PSMD14 significantly inhibited cell growth and caused G1 arrest and cellular senescence by increasing p21 stability in LUAD cells."
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"Compared to PSMD14-Ctrl cells, the overexpression of PSMD14 promoted BC cell growth according to the CCK8 assay (Fig. 4C)."
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"Conversely, PSMD14 overexpression promoted BC cell growth in vitro and in vivo."
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"The restoration of E2F1 or Survivin expression in liver cancer cells substantially counteracted POH1 deletion induced cell growth inhibition and apoptotic response (XREF_FIG; XREF_SUPPLEMENTARY)."
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"Importantly, the loss of Smad3 abolished POH1-induced cell growth sharply ( Fig. 6 I, Fig. S1C )."
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"In addition, it has also been shown that PSMD14 can promote cell growth in vitro and tumor development in vivo (Lv et al., 2020)."
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"Targeting POH1 inhibits prostate cancer cell growth and enhances the suppressive efficacy of androgen deprivation and docetaxel."
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