IndraLab

Statements

CCL5 binds CXCR4. 10 / 12
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"For example, inhibition of platelet derived CXCR4–CCL5 heterodimer formation was shown to attenuate monocyte recruitment to inflamed vessel wall inApoE −/− mice xref and also reduce aneurysm formation in those animals."
25468720
sparser
"Another recent mouse study presented protective and anti-inflammatory effects of MKEY (a specific peptide blocking the CCL5-CXCR4 interaction) in a myocardial ischemia/reperfusion injury model and suggested that it could be used therapeutically in atherosclerosis and myocardial infarction treatment [ xref ]."
33503867
sparser
"The downregulation of CXCR4 was specific for SDF-1α and was not observed when the cells were treated with RANTES, which does not bind CXCR4 (Fig. xref , a–c )."
9207008
sparser
"A specifically designed compound (MKEY) to block this CCL5-CXCR4 interaction is investigated as a potential therapeutic in a model of myocardial ischemia/reperfusion (I/R) damage."
30006564
sparser
"To examine the effects of MKEY in healing following I/R, 8 week-old male mice were treated with MKEY or sMKEY to block specific CCL5-CXCR4 interactions."
30006564
sparser
"Furthermore, administration of a CCL2 competitor reduced monocyte recruitment, which attenuated MI-R injury ( xref ), and pharmacological blockage of the CCL5-CXCR4 interaction impaired the inflammatory response resulting in a reduced infarct size and preserved cardiac function ( xref )."
33996944
reach
"For example, inhibition of platelet derived CXCR4 and CCL5 heterodimer formation was shown to attenuate monocyte recruitment to inflamed vessel wall in ApoE -/- mice XREF_BIBR and also reduce aneurysm formation in those animals."
25468720
sparser
"The β chemokine Rantes, which does not bind CXCR4, had no effect on infection."
9348282
reach
"CCL3 and MIP1alpha binding to CCR5 STA mutant receptor reduced its ability to form heterodimer with CXCR4, while the binding of CCL5 and RANTES to CCR5 or CXCL12 and SDF -1 to CXCR4 had no apparent effect."
18923649
reach
"FGF21 synergistically blocks CXCR4 and CCL5 interaction on the hepatocytes to inhibit the production of TGFbeta, IL-6, IL-1, RANTES, Col1, and elastin."
32483404