IndraLab

Statements

CCL5 binds CXCR4. 12 / 14
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"Furthermore, administration of a CCL2 competitor reduced monocyte recruitment, which attenuated MI-R injury ( xref ), and pharmacological blockage of the CCL5-CXCR4 interaction impaired the inflammatory response resulting in a reduced infarct size and preserved cardiac function ( xref )."
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"For example, inhibition of platelet derived CXCR4–CCL5 heterodimer formation was shown to attenuate monocyte recruitment to inflamed vessel wall inApoE −/− mice xref and also reduce aneurysm formation in those animals."
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"To examine the effects of MKEY in healing following I/R, 8 week-old male mice were treated with MKEY or sMKEY to block specific CCL5-CXCR4 interactions."
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"For example, inhibition of platelet derived CXCR4 and CCL5 heterodimer formation was shown to attenuate monocyte recruitment to inflamed vessel wall in ApoE -/- mice XREF_BIBR and also reduce aneurysm formation in those animals."
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"Additionally, obstructing the interaction between CC motif chemokine 5 (CCL5) and CXC motif chemokine receptor 4 (CXCR4) in MI shrank infarct size, conserved heart function, and was related to a reduced presence of neutrophils and the formation of neutrophil extracellular traps [34]."
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"The downregulation of CXCR4 was specific for SDF-1α and was not observed when the cells were treated with RANTES, which does not bind CXCR4 (Fig. xref , a–c )."
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"Another recent mouse study presented protective and anti-inflammatory effects of MKEY (a specific peptide blocking the CCL5-CXCR4 interaction) in a myocardial ischemia/reperfusion injury model and suggested that it could be used therapeutically in atherosclerosis and myocardial infarction treatment [ xref ]."
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"FGF21 synergistically blocks CXCR4 and CCL5 interaction on the hepatocytes to inhibit the production of TGFbeta, IL-6, IL-1, RANTES, Col1, and elastin."
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"CCL3 and MIP1alpha binding to CCR5 STA mutant receptor reduced its ability to form heterodimer with CXCR4, while the binding of CCL5 and RANTES to CCR5 or CXCL12 and SDF -1 to CXCR4 had no apparent effect."
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"The β chemokine Rantes, which does not bind CXCR4, had no effect on infection."
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"A specifically designed compound (MKEY) to block this CCL5-CXCR4 interaction is investigated as a potential therapeutic in a model of myocardial ischemia/reperfusion (I/R) damage."
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"The immune checkpoint module (Figure 7A) revealed interactions between CCL5, CCR1, CXCL12, and CXCR4."
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