IndraLab

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Estradiol activates KCNMA1. 7 / 7
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"If DHS-I and estradiol also activate Slo1 core and Slo3 tail channels only in the presence of the beta1 subunit, then this would suggest that the beta1 subunit is also functionally associated with Slo1 core and Slo3 tail channels."
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"The application of estradiol with propranolol, a beta-adrenergic receptor blocker, did not increase BK channel opening."
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"10 μM estradiol activated BK channel to a similar degree like 1 μM intracellular calcium."
10828459
eidos
"Thus , this regulatory subunit is necessary for the activation of BK channels by estradiol ( Granados et al ., 2019 ) , and for channel activation and eventual cerebrovascular dilation by cholanes and derivatives ( Bukiya et al ., 2011 , 2013 ) ."
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"We investigated whether 17beta estradiol increased the probability of the BK channel opening (NP0)."
| PMC
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"Interestingly, 17 beta estradiol has been reported to increase BK channel function and, thus, relax vascular smooth muscle, via several mechanisms, including a direct interaction with BK beta1 subunits [XREF_BIBR, XREF_BIBR]."
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"10 muM estradiol activated BK channel to a similar degree like 1 muM intracellular calcium.The biochemical purification of BK channels from tracheal smooth muscle showed that they are coassembled from[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10828459