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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PI3K inhibits COPS5. 2 / 2

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"We explored a potential connection between PI3K activity and Jab1 and E2F1 target gene induction, and found that E2F1 and Jab1 co-induction of apoptotic target genes can be inhibited by activated PI3K."

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"Besides, PI3K and Akt may participate in the regulation of Jab1 and COPS5 by Bcr-Abl since PI3K and Akt inhibitor LY294002 decreases the promoter activity and mRNA level of Jab1 and COPS5."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...