IndraLab

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"To evaluate in mammalian rod photoreceptors the selectivity for hyperpolarization activated cyclic nucleotide gated (Hcn1, coded by Hcn1) over potassium selective (Kir 2.4, coded by Kcnj14) channels of ivabradine, a selective inhibitor of the cardiac " funny " current (I (f))."

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"Another gene of interest is the Hcn1 gene that encodes a hyperpolarization-activated cyclic-nucleotide-gated K+ channel and plays important roles in regulating synaptic plasticity and neurotransmitter release (Biel et al., 2009)."