IndraLab

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OTUD6B increases the amount of IRF3. 2 / 2
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"OTUD6B knockdown strongly downregulated cellular IRF3 protein levels but not IRF3 mRNA level (Fig. 5A)."
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"Our results showed that overexpression of OTUD6B, and not defective OTUD6B-C57S, dramatically attenuated the ubiquitination levels of exogenously expressed IRF3, demonstrating that OTUD6B does reduce IRF3 ubiquitination levels and its deubiquitinase activity is critical (Fig. 5C)."
37650650