IndraLab

Statements

MINK1 inhibits KCNQ1. 6 / 6
| 6
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"Further, the F340W mutation alters the effects of MinK on KCNQ1 on both activation and inactivation : MinK increases inactivation and constitutive activation of F340W-KCNQ1, whereas MinK removes inact[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18567635
reach
"MinK eliminates inactivation of wild-type KCNQ1 channels, in contrast to our observations for F340W-I Ks channels (33,34)."
18567635
reach
"The MinK ancillary subunit slows KCNQ1 activation, eliminates its inactivation, and increases its unitary conductance."
19202166
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"In the same study, CHO cell expression experiments showed that MinK prevented modulation of KCNQ1 by MiRP1, but that MiRPs 2-4 could override effects of MinK on KCNQ1-thus KCNQ1 may be modulated by multiple MiRPs in human heart depending on sub-tissue or even subcellular distribution and other temporal or regulatory factors."
19219384
reach
"A MinK deletion mutant with amino acids 94-129 deleted was able to slow KvLQT1 activation, shift the voltage dependence of activation to more positive potentials, and remove inactivation."
10962015
reach
"Upon depolarization, MinK Delta79-129 slowed KvLQT1 activation to a lesser extent than wild-type MinK (XREF_FIG A, right center)."
10962015