IndraLab

Statements

reach
"Since nucleus exportation is a prerequisite step for USP3 to target MyD88 and inhibit NF‐κB signaling activation, we hypothesized that LPS priming could result in the retention of USP3 in the cytoplasm."
37971847
reach
"Consistently, LPS priming resulted in the cytoplasmic retention of USP3 in control THP‐1 cells (Fig EV5C)."
37971847
reach
"Although we observed the existence of cytoplasmic USP3 even without LPS stimulation in USP3‐expressing THP‐1 cells, possibly due to the overexpression of USP3, LPS pretreatment still increased the amount of cytoplasmic USP3 in these cells (Fig EV5C), indicating that LPS‐pretreatment induces the cytoplasmic retention of both endogenous and exogenous USP3 in THP‐1 cells."
37971847
reach
"LPS priming resulted in the cytoplasmic retention of USP3, which enabled it to remove the K63‐linked polyubiquitin chains more efficiently on MyD88 and attenuate subsequent NF‐κB signaling upon a second LPS challenge."
37971847
reach
"At the same time, LPS pretreatment can induce the cytoplasmic retention of USP3 and a rapid and intense transfer to the cytoplasm upon a second LPS challenge, which allows USP3 to rapidly shut down NF-κB signaling [77]."
38927085