IndraLab

Statements

CYLD activates TARDBP. 3 / 3
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"In turn, expression of CYLD -GFP (Fig. 4m–p) caused a further 1.3-fold increase in cytoplasmic/nuclear TDP-43 relative to CYLD -GFP (0.121 ± 0.002; p < 0.0001; Fig. 4q–s)."
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"Pharmacological intervention with the apoptosis inducer staurosporine and mutation in a secondary gene (CYLD) also induced measurable cytoplasmic mislocalisation of endogenous FUS and TDP-43, respectively."
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"Moreover, this M719V variant of CYLD impairs autophagosome maturation and increases the cytosolic localization of TDP-43."
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