IndraLab

Statements

USP18 inhibits interaction. 3 / 3
| 1 2
sparser
"UBP43 binds to IFNAR2 and inhibits the interaction between JAK1 and IFNAR2; this is independent of its isopeptidase activity."
18802094
sparser
"The isopeptidase activity of UBP43 responsible for deconjugation of ISG15ylated proteins, however, is not required for the inhibition of STAT1 phosphorylation, which appears to be mediated instead through direct inhibition by UBP43 of the interaction of JAK1 with the type I IFN receptor xref ."
19551150
eidos
"USP18 specifically interacts with the IFNAR2 subunit to inhibit the interaction between JAK and the IFN receptor ( 60 ) ."
30671058