IndraLab

Statements

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"In contrast, OTUB1 *, which has been engineered to have increased DUB activity compared with OTUB1, showed some activity toward autoubiquitinated HECTD1 (XREF_FIG A, OTUB1 * lanes 3-5 versus 2; Fig.S2C for His 6 -HECTD1 CD)."
| PMC
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"These data suggested that F508del-CFTR stabilization by a fully synthetic DUBTAC might be possible, and the relatively minimal OTUB1 occupancy of the covalent 26 might still allow endogenous DUB function."
35377645
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"Several studies have shown that OTUB1 modulates the ubiquitination levels of target proteins independent of its deubiquitinase activity."
30709928
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"As shown in XREF_FIG, the stability of SLC7A11 was effectively rescued by OTUB1 (C91A) but not by OTUB1 (D88A), suggesting that OTUB1 promotes SLC7A11 stabilization independent of its deubiquitinase activity."
30709928