IndraLab
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"These approaches allowed identifying a mitophagic effect of USP8 down-regulation, which was clearly detectable in vivo in the fly brain and also in neurons of human origin.Interestingly, USP8 down-regulation promoted basal mitophagy in a Parkin-independent fashion (Figure 2D,E), whereas it inhibited Parkin mitochondrial translocation and mitophagy under stress condition (Supplementary Figure S3)."
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"A study has shown that under the conditions of high glucose and high fat in vivo and in vitro, the S-sulfhydrylation of USP8 was significantly reduced, while after exogenous H S treatment, the S-sulfhydrylation level of USP8 was increased, promoting the combination of USP8 and Parkin."