IndraLab

Statements

USP7 increases the amount of MYCN. 4 / 4
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"HAUSP knockdown reduced levels of N-Myc but had no obvious impact on c-Myc levels (XREF_FIG); similar results were obtained in native H1299 and human colon cancer HCT116 cell lines (XREF_SUPPLEMENTARY)."
27618649
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"However, further experiment indicated that only BAP1 and USP7 could elevate the MYCN protein level in a dose-dependent manner, but BAP1 have the best effect on the elevation of MYCN protein levels (Fig. 1F)."
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"USP7 Inhibition and USP7 Depletion Leads to Decreased N-Myc Protein Expression."
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"In addition, USP7 inhibition led to decreased N-myc protein levels in both MYCN-amplified and -nonamplified NB cell lines, but no correlation was observed between MYCN amplification and treatment response."
37762082