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USP6 activates Wnt/β-catenin. 2 / 2
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"USP6 functions as a deubiquitinase and a designated oncogene, responsible for various cancers and sarcomas progression.USP6 modulates key pathways like NF-κB, JAK-STAT and Wnt/β-catenin driving tumor progression and inflammation.USP6 is implicated in a variety of cell biological processes, including cell cycle regulation, proliferation, invasion, migration, and DNA damage repair."
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"In nodular fasciitis, chromosomal translocations cause overexpression of USP6, which activates the Wnt/β-catenin pathway [51]."
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