IndraLab

Statements

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"We propose that syntrophin gamma 2 is an essential Na(+) channel-interacting protein required for the full expression of the Na(+) current and that the SCN5A-syntrophin gamma 2 interaction determines mechanosensitivity and current availability."
12429735
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"For example, disrupted association of the SCN5A complex with the sarcomere protein syntrophin has been implicated in a variant of long QT syndrome ( xref )."
23650201
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"Moreover, interactions between Nav1.5 and α 1 -syntrophin increased the membrane density of Kir2 channels and were necessary for the Nav1.5-Kir2 positive reciprocal regulation [84] ."
36596415
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"Deletion of the SIV motif abolished the interaction between Nav1.5 and syntrophin, specifically localized at lateral membranes, as opposed to their expected reduction of Nav1.5 channels at lateral mem[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36596415
sparser
"It indirectly interacts with Nav1.5 via syntrophin, which binds with the C-terminus of dystrophin and with the SIV motif on the C-terminus of Nav1.5 ( xref ; xref )."
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